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Alopecia occurs commonly in patients treated with cyclophosphamideThe hair can be expected to grow back after treatment with the drug or even during continued drug treatmentthough it may be different in texture or colorSkin rash occurs occasionally in patients receiving the drugPigmentation of the skin and changes in nails can occurVery rare reports of Stevens-Johnson syndrome and toxic epidermal necrolysis have been received during postmarketing surveillancedue to the nature of spontaneous adverse event reportinga definitive causal relationship to cyclophosphamide has not been established.

Use with caution in patients with hepatic or renal impairmentleukopeniathrombocytopeniarecent radiation therapy or chemotherapy.

CUse with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies done.


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