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The dose must be strictly adhered toespecially the 14-days lead-in periodsee section 4.2
The additional studies showed that the prolonged-release tablets best national pharmacy. were as effective as the immediate-release tablets in HIV-infected patientsThey also showed that patients can be safely switched from immediateto prolonged-release tablets.
Viramune administration above the recommended dose might increase the frequency and seriousness of skin reactionssuch as Stevens-Johnson syndrome and toxic epidermal necrolysis.
Nevirapine metabolitesStudies using human liver microsomes indicated that the formation of nevirapine hydroxylated metabolites was not affected by the presence of dapsonerifabutinrifampicinand trimethoprim/sulfamethoxazoleKetoconazole and erythromycin significantly inhibited the formation of nevirapine hydroxylated metabolites.
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telbivudine and viramune may be coadministered without dose adjustments.