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Cyclosporine increased rosuvastatin exposureAUC7foldThereforein patients taking cyclosporinethe dose of CRESTOR should not exceed 5 mg once dailysee DOSAGE AND ADMINISTRATIONWARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY

After initiation or upon titration of CRESTORlipid levels should be analyzed within 2 to 4 weeks and the dosage adjusted accordingly.

CRESTOR is a selective and competitive inhibitor of HMG-CoA reductasethe rate-limiting enzyme that converts 3-hydroxy3methylglutaryl coenzyme A to mevalonatea precursor of cholesterolIn vivo studies in animalsand in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake intoand selectivity foraction in the liverthe target organ for cholesterol loweringIn in vivo and in vitro studiesrosuvastatin produces its lipid-modifying effects in two waysFirstit increases the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDLSecondrosuvastatin inhibits hepatic synthesis of VLDLwhich reduces the total number of VLDL and LDL particles.

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astrazeneca still claims the product is more potent per milligram than other statins available, so in theory patients who require larger dosages of other statins could be treated at a lesser cost using crestor.