Indinavir is an inhibitor of the hepatic isoenzyme cyp3a4; rilpivirine is metabolized by this isoenzyme.

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Milk thistleone study has found decreased indinavir levels in some userswhile another study has notVitamin Cone smallshort-term study has found a small but significant decrease in indinavir levels when 1 gram/day of vitamin C was also taken.

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Selected laboratory abnormalities of severe or life-threatening intensity reported in patients treated with CRIXIVAN aloneCRIXIVAN in combination with zidovudine or zidovudine plus lamivudinezidovudine aloneor zidovudine plus lamivudine are presented in Table 11.

Some drugs can interact with indinavirincreasing or decreasing its levels in your bodyIncreased drug levels can cause you to experience side effects or make pre-existing side effects worseOn the other handif drug levels become too lowHIV can develop resistance and your future treatment options may be reduced.

Clinically significant adverse reactionspotentially leading to severelife-threateningor fatal doxiac. events from greater exposures of concomitant medicationsClinically significant adverse reactions from greater exposures of CRIXIVANLoss of therapeutic effect of CRIXIVAN and possible development of resistance.

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