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Decreases in estrogen levels after oophorectomy or menopause lead to increases in bone resorption and accelerated bone lossBone is initially lost rapidly because the compensatory increase in bone formation is inadequate to offset resorptive lossesIn addition to loss of estrogenthis imbalance between resorption and formation may be due to age-related impairment of osteoblasts or their precursorsIn some womenthese changes will eventually lead to decreased bone massosteoporosisand increased risk for fracturesparticularly of the spinehipand wristVertebral fractures online pharmacy paypal accepted. are the most common type of osteoporotic fracture in postmenopausal women.

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